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The reasons
for choosing
Suplasyn 1-Shot
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Advantages of only 1 injection

  • Time savingTime saving (3)
  • Patient compilancePatient Compliance (1)
  • Reduction of riskReduction of risk of post-injection infection (3)
  • Reduction of the costReduction of the cost of treatment (1,3)

6 month patient relief Up to 6 month significant
pain relief
and improvement
of functionality (1)

Very good safety profile Very good safety profile

Intended for single administration Intended for single administration.

Up to 6 month significant pain relief
and improvement of functionality (1)

Results after 1 injection of suplasyn® 1-shot only at month 3 and 6
Significant improvement in functionallity:+34.9%*
Lequesne index score
Results table 01
Month 3
Month 6

The Lesquene index measured at 3 and 6 months after a Suyplasyn® 1-Shot injection was significant lower than the baseline score

Relevant decrease in VAS pain scores
at rest
mm (EVA)
Results table 02
VAS at rest
VAS walking
Month 3
Month 6

* Month 6 vs Baseline
Significant decrease in pain scores determined from the VAS as measured by the patient at 3 and 6 months after Suplasyn® 1-Shot injection

Very good safety profile

98% No adverse events (3)

Suplasyn® 1-shot has shown less 2.2% adverse events than referenced by high MW HA in other studies (2)

Patient satisfaction at month 3 (1)
  • 86.7% of patients declared an
    improvement in their health
Patient satisfaction at month 6 (1)
  • 88% of patients would repeat the
    treatment with Suplasyn® 1-Shot
  • SUPLASYN® 1-Shot is intended to be a single administration (1)
  • Up to 6 MONTH clinical effect on pain and functionality (1) *
  • OPTIMUM MOLECULAR Weight: optimum stimulation of endogenous Hyaluronic
    Acid synthesis & increased access to diseased tissue (4)
  • EASY for doctors to inject (low viscosity)
  • Very good SAFETY (1,2)
At least 6 months

1. Blanch J et al. ASKOT STUDY: Effectiveness and safety of a 1-shot injection of sodium Hyaluronate for knee osteoarthritis treatment. Springer Experience & Drug Evidence.
2. Chevalier X. et al. Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial. Ann Rheum Dis 2010;69:113–119.
3. D. Van Linthoudt and U.E. Gasser. Evaluation of the analgesic efficacy and short-term tolerance of a single 6 ml injection of hyaluronic acid (Suplasyn® 1-Shot) on osteoarthritis of the knee. Dolor. 2013;28:89-92.
4. Vitanzo C et al. Hyaluronans: Is clinical effectiveness dependent on molecular weight?The American Journal of Orthopedics. 2006; 421-28.

* This depends on patient's individual response

Suitable for larger
synovial joints
Injection techniques