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The reasons
for choosing
Suplasyn 1-Shot
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Advantages of only 1 injection

  • Time savingTime saving (3)
  • Patient compilancePatient Compliance (1)
  • Reduction of riskReduction of risk of post-injection infection (1)
  • Reduction of the costReduction of the cost of treatment (1,3)

6 month patient relief Up to 6 months significant
pain relief
and improvement
of functionality (1)

Very good safety profile Very good tolerability

Intended for single administration Only 1 injection.

Up to 6 months significant pain relief

Results after 1 injection of suplasyn® 1-shot follow up at month 3 and 6
Significant improvement in functionallity:-35.8%*
Functionality results index
Results table 01
Month 3
Month 6

The survey results measured at 3 and 6 months after a Suplasyn® 1-shot injection was significantly lower than the baseline results

Relevant decrease in VAS** pain scores
at rest
mm (EVA)
Results table 02
VAS** at rest
VAS** walking
Month 3
Month 6

Significant decrease in pain scores determined from the VAS** as measured by the patient at 3 and 6 months after Suplasyn® 1-Shot injection

* Month 6 vs Baseline
** Visual Analog Score

Very good tolerability

Suplasyn® 1-shot has shown that 2.2% of the population reported experiencing adverse events.

Patient satisfaction at month 3 (1)
  • 86.7% of patients declared an
    improvement in their health
Patient satisfaction at month 6 (1)
  • 80.6% of patients declared improvement
    at 6 months post injection
  • SUPLASYN® 1-Shot is intended to be a single administration (1)
  • Up to 6 MONTHS clinical effect on pain and functionality (5) *
  • OPTIMUM MOLECULAR Weight: optimum stimulation of endogenous Hyaluronic
    Acid synthesis & easy access to diseased tissue (4)
  • EASY for doctors to inject (low viscosity)
  • Very good SAFETY (5)
At least 6 months

1. Blanch J et al. ASKOT STUDY: Effectiveness and safety of a 1-shot injection of sodium Hyaluronate for knee osteoarthritis treatment. Springer Experience & Drug Evidence.
2. Chevalier X. et al. Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial. Ann Rheum Dis 2010;69:113–119.
3. D. Van Linthoudt and U.E. Gasser. Evaluation of the analgesic efficacy and short-term tolerance of a single 6 ml injection of hyaluronic acid (Suplasyn® 1-Shot) on osteoarthritis of the knee. Dolor. 2013;28:89-92.
4. Maheu E., Rannou F., Reginster J. Y., Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum 45, S28-33 (2016).
5. Petrella RJ : Hyaluronic Acid in treatment of Osteoarthritis of the Shoulder Abstract from the 61th Annual European Congress of Rheumatology (EULAR) 8-11 Juni 2005

* This depends on patient's individual response

Suitable for larger
synovial joints
Injection techniques